The FEAR Before MEN: networks of mitotic exit.

Teodora Pene Dumitrescu, William S Saunders

Department of Biological Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA. dtp3@pitt.edu

Cell cycle (Georgetown, Tex.) 2002 Sep-Oct

filter terms:

Variations in the normal regulation of the mitotic cell cycle can lead to such global cellular changes as differential development or malignant transformation. Studies on the control of mitosis are particularly important to discover the details of the basic mechanisms responsible for normal cell division, as well as to learn about strategies employed by cancerous cells to indefinitely proliferate. The past years have brought noteworthy progress in elucidating the molecular pathways that regulate crucial events during mitosis such as: chromosome condensation, formation of the mitotic spindle, chromosome segregation, cytokinesis, and disassembly of the mitotic spindle.