A new lignan glycoside and other constituents from Cephalaria ambrosioides.

Sofia Pasi, Nektarios Aligiannis, Alexios-Leandros Skaltsounis, Ioanna B Chinou

Division of Pharmacognosy, Department of Pharmacy, University of Athens, University Campus of Zografou, Athens 15771, Greece.

Natural product letters 2002 Dec

filter terms:

A new lignan glycoside, 1,5-dihydroxy-2-(4"-beta-D-glucopyranosyloxy-3"-methoxyphenyl)-6-(4'-hydroxy-3'-methoxyphenyl)-3,7-dioxabicyclo[3.3.0]octane, named ambrosidine ([structure: see text]), along with seven known compounds (four iridoids and three hydroxycinnamic esters) were isolated from the roots of Cephalaria ambrosioides. The structures of these compounds were determined by use of NMR and MS techniques and by chemical transformations. The cytotoxic activity of the novel compound [structure: see text] was evaluated against five human solid tumour cell lines.

Citation

Sofia Pasi, Nektarios Aligiannis, Alexios-Leandros Skaltsounis, Ioanna B Chinou. A new lignan glycoside and other constituents from Cephalaria ambrosioides. Natural product letters. 2002 Dec;16(6):365-70