Isolation of labradorins 1 and 2 from Pseudomonas syringae pv. coronafaciens.

George R Pettit, John C Knight, Delbert L Herald, Richard Davenport, Robin K Pettit, Bruce E Tucker, Jean M Schmidt

Cancer Research Institute and Department of Chemistry and Biochemistry, Arizona State University, Tempe, AZ 85287-2404, USA.

Journal of natural products 2002 Dec

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Investigation of Pseudomonas syringae pv. coronafaciens cancer cell growth inhibitory constituents led to the isolation of 2-isobutyl-5-(3-indolyl)oxazole (1) and 2-n-pentyl-5-(3-indolyl)oxazole (2f), designated labradorins 1 (1) and 2 (2f), related to pimprinine (2a). The structures were deduced by spectroscopic techniques and X-ray crystal structure determinations. Labradorin 1 (1) afforded GI(50) microg/mL values of 9.8 and 6.2 against the human cancer cell lines NCI-H 460 (lung-NSC) and BXPC-3 (pancreas-a).

Citation

George R Pettit, John C Knight, Delbert L Herald, Richard Davenport, Robin K Pettit, Bruce E Tucker, Jean M Schmidt. Isolation of labradorins 1 and 2 from Pseudomonas syringae pv. coronafaciens. Journal of natural products. 2002 Dec;65(12):1793-7