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A portion of autistic patients exhibit compulsive-like behaviours. In addition it has been suggested that serotonin plays a major role in both obsessive compulsive disorder (OCD) and autistic disorder. Other neurohumors such as endogenous opioids and oxytocin have also been implicated in the two disorders. There is also some pharmacological overlap between the two disorders, as well as some similar neuroimaging studies. These similarities and overlaps have led us to propose a putative OCD-autistic disorder, which should be studied in greater detail.


R Gross-Isseroff, H Hermesh, A Weizman. Obsessive compulsive behaviour in autism--towards an autistic-obsessive compulsive syndrome? The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry. 2001 Oct;2(4):193-7

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PMID: 12587149

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