ABT-773: pharmacokinetics and interactions with ranitidine and sucralfate.

M W Pletz, V Preechachatchaval, J Bulitta, M Allewelt, O Burkhardt, H Lode

Antimicrobial agents and chemotherapy 2003 Mar

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We assessed the pharmacokinetics and interaction of ABT-773 in 12 volunteers receiving ABT-773 alone or concomitantly with ranitidine or sucralfate. Data for 150 mg of ABT-773 were as follows: the maximum concentration of the drug in plasma (C(max)) was 318 ng/ml, its half-life was 5.66 h, and its area under the plasma concentration-time curve from 0 h to infinity (AUC(0- infinity )) was 1,662 ng. h/ml. Coadministration of ranitidine, reduced the C(max) (-25.7%) and AUC(0- infinity ) (-15.8%) significantly. Sucralfate had no impact on the bioavailability of ABT-773.

Citation

M W Pletz, V Preechachatchaval, J Bulitta, M Allewelt, O Burkhardt, H Lode. ABT-773: pharmacokinetics and interactions with ranitidine and sucralfate. Antimicrobial agents and chemotherapy. 2003 Mar;47(3):1129-31