Helicobacter pylori infection: CagA-specific antibodies are associated with clinical outcome, but not with HLA-class II polymorphisms of the host.

Erdmute Kunstmann, Cornelia Hardt, Jean E Crabtree, Sebastian Suerbaum, Jörg T Epplen

Department of Human Genetics, Ruhr-University, Bochum, Germany. Erdmute.Kunstmann@ruhr-uni-bochum.de

International journal of medical microbiology : IJMM 2003 Feb

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In order to investigate the interrelation between immunogenetic host and bacterial factors the T-cell receptor (TCR) polymorphism TCRBV6S1 A/B, HLA-DRB1 alleles and cagA status was analyzed in 380 unrelated German individuals. H. pylori infection with cagA-positive bacterial strains was significantly associated with peptic ulcer disease in the German cohort. Patients homozygous for the non-functional TCRBV6S1B allele and presenting with peptic ulcer disease showed no CagA-specific antibodies in the majority of cases. There was no association between HLA-DRB1 alleles and the CagA status of infected individuals, although certain alleles show significant association to the infection status in different populations.

Citation

Erdmute Kunstmann, Cornelia Hardt, Jean E Crabtree, Sebastian Suerbaum, Jörg T Epplen. Helicobacter pylori infection: CagA-specific antibodies are associated with clinical outcome, but not with HLA-class II polymorphisms of the host. International journal of medical microbiology : IJMM. 2003 Feb;292(7-8):537-40