MKK4 and metastasis suppression: a marriage of signal transduction and metastasis research.

Victoria L Robinson, Jonathan A Hickson, Donald J Vander Griend, Zita Dubauskas, Carrie W Rinker-Schaeffer

Section of Urology, Department of Surgery, The University of Chicago (The Committee on Cancer Biology), University of Chicago, Chicago, Illinois 60637, USA.

Clinical & experimental metastasis 2003

filter terms:

MAP kinase kinase 4 (MKK4) is a member of the stress-activated protein kinase (SAPK) signaling cascade and is involved in the regulation of many cellular processes. We have recently demonstrated a functional role for MKK4 in the suppression of metastases. In this review, we discuss the established cellular and biochemical functions of MKK4, as well as a new function for MKK4 as a metastasis suppressor gene. Because of the importance of signaling studies to this translational work, a detailed example of the strategy and tools that can be employed to define the biochemical mechanism of MKK4-mediated metastasis suppression is presented. Finally, the potential therapeutic utility of these findings is discussed.

Citation

Victoria L Robinson, Jonathan A Hickson, Donald J Vander Griend, Zita Dubauskas, Carrie W Rinker-Schaeffer. MKK4 and metastasis suppression: a marriage of signal transduction and metastasis research. Clinical & experimental metastasis. 2003;20(1):25-30