3H]-(R)-NPTS, a radioligand for the type 1 glycine transporter.

John A Lowe, Susan E Drozda, Katherine Fisher, Christine Strick, Lorraine Lebel, Christopher Schmidt, Donna Hiller, Kathleen S Zandi

Central Research Division, Pfizer Inc., Groton, CT 06340, USA. john_a_lowe@groton.pfizer.com

Bioorganic & medicinal chemistry letters 2003 Apr 7

filter terms:

The synthesis of NPTS, 6, a potent inhibitor of the type 1 glycine transporter (GlyT1) is described, as well as preparation of 6 in optically active and tritiated form for use as a radioligand for affinity displacement assay of GlyT1.

Citation

John A Lowe, Susan E Drozda, Katherine Fisher, Christine Strick, Lorraine Lebel, Christopher Schmidt, Donna Hiller, Kathleen S Zandi. 3H]-(R)-NPTS, a radioligand for the type 1 glycine transporter. Bioorganic & medicinal chemistry letters. 2003 Apr 7;13(7):1291-2