Steroidal glycosides from the rhizomes of Dioscorea spongiosa.

Jun Yin, Kyoji Kouda, Yasuhiro Tezuka, Quan Le Tran, Tatsuro Miyahara, Yingjie Chen, Shigetoshi Kadota

Institute of Natural Medicine and Faculty of Pharmaceutical Science, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Japan.

Journal of natural products 2003 May

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A water extract of the rhizomes of Dioscorea spongiosa, which showed antiosteoporotic activity, was examined, and four new pregnane glycosides, named spongipregnolosides A-D (1-4), and two new cholestane glycosides, named spongiosides A (5) and B (6), were isolated together with 15 known glycosides. Their structures were determined on the basis of spectroscopic analysis and chemical methods. Among the isolated compounds, spongioside A (5), hypoglaucin G (7), methylprotodioscin (8), and (R)-oct-1-en-3-yl O-alpha-l-arabinopyranosyl-(1-->6)-alpha-d-glucopyranoside (9) showed potent inhibition against bone resorption induced by parathyroid hormone in a bone organ culture system.

Citation

Jun Yin, Kyoji Kouda, Yasuhiro Tezuka, Quan Le Tran, Tatsuro Miyahara, Yingjie Chen, Shigetoshi Kadota. Steroidal glycosides from the rhizomes of Dioscorea spongiosa. Journal of natural products. 2003 May;66(5):646-50