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Modification of the cladinose C-4" position via manipulation of the corresponding keto derivatives afforded two stereochemically pure series of compounds. The synthesis and structure determination of these compounds is described within. The in vitro and in vivo biological activity of this novel series of C-4" modified macrolides is also described.


Brian S Bronk, Michael A Letavic, Camilla D Bertsche, David M George, Shigeru F Hayashi, Barbara J Kamicker, Nicole L Kolosko, Laura J Norcia, Margaret A Rushing, Sheryl L Santoro, Bingwei V Yang. Synthesis, stereochemical assignment and biological activity of a novel series of C-4" modified aza-macrolides. Bioorganic & medicinal chemistry letters. 2003 Jun 16;13(12):1955-8

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PMID: 12781172

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