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The practical and convenient synthesis of hotrienol, which is an excellent fruity smelling compound, has been performed by the ene-type chlorination of linalyl acetate and then dehydrochlorinated by lithium bromide and lithium carbonate in DMF, followed by hydrolysis in three steps with an overall yield of 55%.

Citation

Yoshifumi Yuasa, Yasushi Kato. A practical and convenient synthesis of hotrienol, an excellent fruity smelling compound. Journal of agricultural and food chemistry. 2003 Jul 2;51(14):4036-9

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PMID: 12822943

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