Warangalone, the isoflavonoid anti-inflammatory principle of Erythrina addisoniae stem bark.

Emmanuel Talla, Dieudonné Njamen, Joseph Tanyi Mbafor, Zacharias Tanee Fomum, Albert Kamanyi, Jean-Claude Mbanya, Rosa M Giner, M Carmen Recio, Salvador Máñez, José Luis Ríos

Department of Organic Chemistry, Faculty of Science, University of Yaounde 1, P.O. Box 812, Yaounde, Cameroon.

Journal of natural products 2003 Jun

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The prenylisoflavone warangalone has been isolated from the bark of Erythrina addisoniae. This compound, previously recognized as a powerful inhibitor of protein kinase A, showed marked effectiveness as an anti-inflammatory on the phospholipase A(2)-induced paw edema and on the 12-O-tetradecanoylphorbol 13-acetate-induced ear edema in mice, after systemic and local administration, respectively.

Citation

Emmanuel Talla, Dieudonné Njamen, Joseph Tanyi Mbafor, Zacharias Tanee Fomum, Albert Kamanyi, Jean-Claude Mbanya, Rosa M Giner, M Carmen Recio, Salvador Máñez, José Luis Ríos. Warangalone, the isoflavonoid anti-inflammatory principle of Erythrina addisoniae stem bark. Journal of natural products. 2003 Jun;66(6):891-3