WF11605, an antagonist of leukotriene B4 produced by a fungus. II. Structure determination.

N Shigematsu, E Tsujii, N Kayakiri, S Takase, H Tanaka, T Tada

Exploratory Research Laboratories, Fujisawa Pharmaceutical Co., Ltd., Ibaraki, Japan.

The Journal of antibiotics 1992 May

filter terms:

The structure of WF11605, a novel tetracyclic triterpene glucoside, was determined to be 1. The plane structure of deacetyl-WF11605 aglycone was elucidated as 2 through the concerted application of a series of 2D NMR techniques. The relative configurations were established by X-ray crystallographic analysis of bis(p-bromobenzoyl) derivative 3 and absolute stereochemistry by CD exciton chirality method.

Citation

N Shigematsu, E Tsujii, N Kayakiri, S Takase, H Tanaka, T Tada. WF11605, an antagonist of leukotriene B4 produced by a fungus. II. Structure determination. The Journal of antibiotics. 1992 May;45(5):704-8