Ptosis and asthenia manifesting a mitochondrial myopathy].

P Disdier, J R Harlé, D Figarella-Branger, A A Chérif, C Desnuelle, P J Weiller

Service de Médecine Interne, Hôpital de la Timone, Marseille.

La Revue de médecine interne / fondée ... par la Société nationale francaise de médecine interne 1992 Sep-Oct

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We report a case of mitochondrial myopathy discovered in a 55-year old woman who was being investigated for the cause of her asthenia. Physical examination showed ptosis of the upper eyelid and proximal muscle deficit. Histological examination of a muscle biopsy disclosed rare fibres with mitochondrial aggregates. Biochemical exploration of muscle tissue revealed a double enzyme deficit involving complexes I and IV of the respiratory chain. Clinical improvement was obtained after the patient was put on coenzyme Q10. We conclude that a diagnosis of mitochondrial myopathy must be considered in patients, including middle-aged adults, presenting with muscular asthenia.

Citation

P Disdier, J R Harlé, D Figarella-Branger, A A Chérif, C Desnuelle, P J Weiller. Ptosis and asthenia manifesting a mitochondrial myopathy]. La Revue de médecine interne / fondée ... par la Société nationale francaise de médecine interne. 1992 Sep-Oct;13(5):381-3