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Antiandrogen. I. 2-azapregnane and 2-oxapregnane steroids.
K Shibata, S Takegawa, N Koizumi, N Yamakoshi, E Shimazawa
Research Department, Teikoku Hormone Mfg. Co., Ltd., Kawasaki, Japan.
Chemical & pharmaceutical bulletin 1992 AprSizes of these terms reflect their relevance to your search.
2-Azachlormadinone acetate (5a, 17-acetoxy-6-chloro-2-azapregna-4,6-diene- 3,20-dione), 2-oxachlormadinone acetate (6, 17-acetoxy-6-chloro-2-oxapregna-4,6-diene-3,20-dione) and the derivatives were prepared as potential antiandrogenic agents. Biological evaluation showed that 5a and 6 had a potent antiandrogenic activity when tested in the castrated male rat.
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K Shibata, S Takegawa, N Koizumi, N Yamakoshi, E Shimazawa. Antiandrogen. I. 2-azapregnane and 2-oxapregnane steroids. Chemical & pharmaceutical bulletin. 1992 Apr;40(4):935-41
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PMID: 1381997
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