The substance responsible for the poisoning effect of ciguatera poison from fish is an anticholinesterase. In rats, mice, and rabbits ciguatera poison causes death by asphyxiation. Protopam chloride with atropine is an effective antidote.
K M LI. CIGUATERA FISH POISON: A CHOLINESTERASE INHIBITOR. Science (New York, N.Y.). 1965 Mar 26;147:1580-1
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PMID: 14260374
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