Modelling the adsorption kinetics of erythromycin onto neutral and anionic resins.

Maria H L Ribeiro, Isabel A C Ribeiro

Faculdade de Farmácia, Biotecnologia Farmacêutica, Av. Gama Pinto, 1649-003 Lisbon, Portugal. mhribeiro@ff.ul.pt

Bioprocess and biosystems engineering 2003 Nov

filter terms:

In this study the selective adsorption method was chosen to enable the recovery of erythromycin. The following sorbents were tested: neutral resins (XAD-4, XAD-7 and XAD-16) and an anionic resin (IRA-410). A mathematical kinetic model for the adsorption of erythromycin against time, on XAD-4, XAD-7 and XAD-16 resins, is proposed. Both Freundlich and Langmuir models showed a good fit for the sorbents XAD-7 and IRA-410 resins. The highest adsorption efficiency was observed when synthetic neutral resin, XAD-7 and XAD-16, were used. The estimated affinity and concentration factors show that the neutral resins tested are adequate for the selective adsorption of erythromycin. The estimated values of enthalpy and free energy of adsorption, lower than 12 kJ mol(-1) and -2 kJ mol(-1), respectively, indicate that a physiosorption process occurred.

Citation

Maria H L Ribeiro, Isabel A C Ribeiro. Modelling the adsorption kinetics of erythromycin onto neutral and anionic resins. Bioprocess and biosystems engineering. 2003 Nov;26(1):49-55