Thiersindoles A-C: new indole diterpenoids from Penicillium thiersii.

Chen Li, James B Gloer, Donald T Wicklow

Department of Chemistry, University of Iowa, Iowa City, Iowa 52242, USA.

Journal of natural products 2003 Sep

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Three new 3-substituted indole diterpenoids (thiersindoles A-C; 1-3) have been isolated from organic extracts of a new Penicillium species (P. thiersii). Their structures, including absolute stereochemistry, were determined by analysis of NMR data and application of Mosher's method. Thiersindoles A-C are biogenetically related to the aflavinines, although the [6,6,5] tricyclic diterpenoid skeleton in compounds 1 and 2 is unprecedented in any of the known members of this class.

Citation

Chen Li, James B Gloer, Donald T Wicklow. Thiersindoles A-C: new indole diterpenoids from Penicillium thiersii. Journal of natural products. 2003 Sep;66(9):1232-5