The synthesis of SO-3, a conopeptide with high analgesic activity derived from Conus striatus.

Qiuyun Dai, Fengyun Liu, Yanrong Zhou, Baisong Lu, Fang Yu, Peitang Huang

Institute of Biotechnology, Beijing 100071, People's Republic of China. qdai@nd.edu

Journal of natural products 2003 Sep

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The synthesis and characterization of the conopeptide, SO-3, originally derived from Conus striatus is reported. It contains 25 amino acid residues and three disulfide bridges and manifests 72% sequence identity with MVIIA, an N-type Ca2+ channel inhibitor of high analgesic activity. We evaluated SO-3 in several mouse models of pain. The results indicate that SO-3 is a potent, nonaddictive, analgesic agent.

Citation

Qiuyun Dai, Fengyun Liu, Yanrong Zhou, Baisong Lu, Fang Yu, Peitang Huang. The synthesis of SO-3, a conopeptide with high analgesic activity derived from Conus striatus. Journal of natural products. 2003 Sep;66(9):1276-9