Is there an evolutionary relationship between WARP (von Willebrand factor A-domain-related protein) and the FACIT and FACIT-like collagens?

Murdoch Childrens Research Institute, University of Melbourne, Royal Children's Hospital, Parkville, Vic. 3052, Australia. fitzgerj@cryptic.rch.unimelb.edu.au

FEBS letters 2003 Sep 25

filter terms:

We suggest that there is an evolutionary relationship between von Willebrand factor A-domain-related protein (WARP), and the fibril-associated collagen with interrupted triple helix (FACIT) and FACIT-like subfamilies of collagens. Data from a comparison of amino acid sequences, domain organisation and chromosomal location are consistent with the hypothesis that WARP and these collagens share a common collagen ancestor. In support of this is the observation that the WARP 3' coding region is GC-rich suggesting that this may represent the remnant of a triple helix protein domain which WARP has 'lost' during evolution.

Citation

Jamie Fitzgerald, John F Bateman. Is there an evolutionary relationship between WARP (von Willebrand factor A-domain-related protein) and the FACIT and FACIT-like collagens? FEBS letters. 2003 Sep 25;552(2-3):91-4