Imaging of adenosine A1 receptors in the human brain by positron emission tomography with [11C]MPDX.

Nobuyoshi Fukumitsu, Kenji Ishii, Yuichi Kimura, Keiichi Oda, Toru Sasaki, Yutaka Mori, Kiichi Ishiwata

Positron Medical Center, Tokyo Metropolitan Institute of Gerontology, Japan. GZL13162@nifty.ne.jp

Annals of nuclear medicine 2003 Sep

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We report the first clinical PET study using [1-methyl-11C]8-dicyclopropylmethyl-1-methyl-3-propylxanthine ([11C]MPDX) for imaging adenosine A1 receptors in the human brain. The binding of [11C]MPDX evaluated quantitatively as the distribution volume by a graphical analysis was high in the striatum and thalamus, and low in the cerebellum. The distribution pattern of [11C]MPDX was coincident with that of adenosine A1 receptors in vitro reported previously, and was different from those of blood flow and [18F]FDG. The [11C]MPDX PET has the potential for mapping adenosine A1 receptors in the human brain.

Citation

Nobuyoshi Fukumitsu, Kenji Ishii, Yuichi Kimura, Keiichi Oda, Toru Sasaki, Yutaka Mori, Kiichi Ishiwata. Imaging of adenosine A1 receptors in the human brain by positron emission tomography with [11C]MPDX. Annals of nuclear medicine. 2003 Sep;17(6):511-5