Application of a novel design paradigm to generate general nonpeptide combinatorial scaffolds mimicking beta turns: synthesis of ligands for somatostatin receptors.

Dona Chianelli, Yong-Chul Kim, Dmitriy Lvovskiy, Thomas R Webb

ChemBridge Research Labs., LLC, 16981 Via Tazon, San Diego, CA 92127, USA.

Bioorganic & medicinal chemistry 2003 Nov 17

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Nonpeptide compounds that mimic bioactive peptides are desirable for a number of clinical indications. We report a new practical method for the design of scaffolds exhibiting drug-like properties that are suitable for the display of peptide pharmacophores. The synthesis of various synthons of 7'-hydroxy-2',3'-dihydro-1'H,2H,5H-spiro[imidazolidine-4,4'-quinoline]-2,5-dione (1) and methods for the introduction of several mimics of amino acid side-chains are described. This method is exemplified by derivatives that show agonist activity for the somatostatin type 2 receptor.

Citation

Dona Chianelli, Yong-Chul Kim, Dmitriy Lvovskiy, Thomas R Webb. Application of a novel design paradigm to generate general nonpeptide combinatorial scaffolds mimicking beta turns: synthesis of ligands for somatostatin receptors. Bioorganic & medicinal chemistry. 2003 Nov 17;11(23):5059-68