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Field isolates of Phoma macrostoma were obtained from diseased Canada thistle growing in several geographically diverse regions. Bleaching and chlorotic symptoms were present on the infected plants. The isolates grown in liquid culture were found to produce phytotoxic metabolites which also caused bleaching when applied foliarly to several broadleaf species. Bioassay-directed isolation led to the discovery of macrocidins A and B, the first representatives of a new family of cyclic tetramic acids. This new chemotype may offer significant potential as a template for herbicide design.


Paul R Graupner, Andy Carr, Erin Clancy, Jeffrey Gilbert, Karen L Bailey, Jo-Anne Derby, B Clifford Gerwick. The macrocidins: novel cyclic tetramic acids with herbicidal activity produced by Phoma macrostoma. Journal of natural products. 2003 Dec;66(12):1558-61

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PMID: 14695796

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