Trypanocidal constituents in plants 3. Leaves of Garcinia intermedia and heartwood of Calophyllum brasiliense.

Fumiko Abe, Shinya Nagafuji, Hikaru Okabe, Hiroshige Akahane, Elizabeth Estrada-Muñiz, Maira Huerta-Reyes, Ricardo Reyes-Chilpa

Faculty of Pharmaceutical Sciences, School of Medicine, Fukuoka University, 8-19-1 Nanakuma, Jonan-ku, Fukuoka 814-0180, Japan. abefumi@fukuoka-u.ac.jp

Biological & pharmaceutical bulletin 2004 Jan

filter terms:

The constituents of the leaves of Garcinia intermedia and heartwood of Calophyllum brasiliense were investigated based on their trypanocidal activity against epimastigotes of Trypanosoma cruzi, the etiologic agent of Chagas' disease. As the active components, the polyisoprenylated benzophenone derivative guttiferone A and the xanthone 8-desoxygartanin were isolated along with the biflavonoids podocarpusflavone A and amentoflavone, and friedelin from the former. Three xanthones, jacareubin, 6-deoxyjacareubin, and 1,3,5,6-tetrahydroxy-2-(3-methyl-2-butenyl)xanthone from the latter showed activity. The trypanocidal activity of these compounds against trypomastigotes, an infectious form of T. cruzi, was examined as well as gossypol, berberine chloride, and harmine for comparison.

Citation

Fumiko Abe, Shinya Nagafuji, Hikaru Okabe, Hiroshige Akahane, Elizabeth Estrada-Muñiz, Maira Huerta-Reyes, Ricardo Reyes-Chilpa. Trypanocidal constituents in plants 3. Leaves of Garcinia intermedia and heartwood of Calophyllum brasiliense. Biological & pharmaceutical bulletin. 2004 Jan;27(1):141-3