Trypanocidal constituents in plants 4. Withanolides from the aerial parts of Physalis angulata.

Shinya Nagafuji, Hikaru Okabe, Hiroshige Akahane, Fumiko Abe

Faculty of Pharmaceutical Sciences, Fukuoka University, 8-19-1 Nanakuma, Jonan-ku, Fukuoka 814-0180, Japan.

Biological & pharmaceutical bulletin 2004 Feb

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The constituents of the aerial parts of Physalis angulata (Solanaceae) were investigated based on the plant's trypanocidal activity against epimastigotes of Trypanosoma cruzi, the etiologic agent for Chagas' disease. Four new withanolides were isolated, along with six known ones, from the active fraction. Their structures were determined by spectroscopic analysis. Trypanocidal activity against trypomastigotes, an infectious form of T. cruzi, was also estimated, as well as cytotoxic activity against human uterine carcinoma (HeLa) cells in vitro. Evaluation of trypanocidal activity using the colorimetric reagent Cell Counting Kit-8 was also examined.

Citation

Shinya Nagafuji, Hikaru Okabe, Hiroshige Akahane, Fumiko Abe. Trypanocidal constituents in plants 4. Withanolides from the aerial parts of Physalis angulata. Biological & pharmaceutical bulletin. 2004 Feb;27(2):193-7