Effects of hypertriglyceridemia on platelet activities in endogenous hypertriglyceridemic patients].

Tao Shen, Bing-wen Liu, Yu Liu, Huai Bai, Zu-hui Zhang

Apolipoprotein Research Unit, West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu 610041, China.

Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition 2004 Jan

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To explore the effects of hypertriglyceridemia on platelet activities. The plasma prothrombin time (PT), activated partial thromboplastin time (APTT), fibrinogen (Fg), blood platelet count (BPC) and platelet alpha granule membrane protein-140 (GMP-140) levels in endogenous hypertriglyceridemic patients were determined, and the relationship between platelet activities and fasting plasma lipids was assessed. It was found that PT, Fg levels, BPC and plasma GMP-140 concentration showed no statistically significant difference between the control and hypertriglyceridemic subjects (P > 0.05). PT was correlated with the levels of plasma BG and apo E (r = 0.500, P = 0.012), the levels of Fg was positively correlated with BG (r = 0.598, P = 0.000), and BPC of HTG subjects was negatively correlated with TG (r = -0.489, P < 0.05). GMP-140 content was positively correlated with the levels of plasma TC and LDL-C (r = 0.647, 0.833, P < 0.01); in HTG patients it was inversely correlated with age and PT (r = -0.480, -0.490, P < 0.05). All of these indicated that increasing of coagulation activity in hypertriglyceridemic patients was correlated with dysfunction of plasma lipids and change of apolipoproteins levels. Plasma GMP-140 was not obviously correlated with plasma TG content, but was positively correlated with plasma TC and LDL-C contents.

Citation

Tao Shen, Bing-wen Liu, Yu Liu, Huai Bai, Zu-hui Zhang. Effects of hypertriglyceridemia on platelet activities in endogenous hypertriglyceridemic patients]. Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition. 2004 Jan;35(1):15-7