All roads lead to Rome: triggering dendritic cell migration.

Uta E Höpken, Martin Lipp

Department of Molecular Tumor Genetics and Immunogenetics, Max-Delbrück-Center for Molecular Medicine, Robert-Rössle-Strasse 10, 13092 Berlin, Germany.

Immunity 2004 Mar

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Migration of dendritic cells to secondary lymphatic organs is a key event in acquired immunity. The role of the multifunctional ectoenzyme CD38 in humoral immune responses has now been revisited, suggesting that CD38 links innate and adaptive immunity by triggering chemokine-mediated dendritic cell chemotaxis.