Role of the cytoskeleton during leukocyte responses.

The cytoskeleton is a cellular network of structural, adaptor and signalling molecules that regulates most cellular functions that are related to the immune response, including migration, extravasation, antien recognition, activation and phagocytosis by different subsets of leukocytes. Recently, a large number of regulatory elements and structural constituents of the leukocyte cytoskeleton have been identified. In this review, we discuss the composition and regulation of the different cytoskeletal elements and their role in immune responses.

Citation

Miguel Vicente-Manzanares, Francisco Sánchez-Madrid. Role of the cytoskeleton during leukocyte responses. Nature reviews. Immunology. 2004 Feb;4(2):110-22

Mesh Tags

Substances

PMID: 15040584

search → result