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The shark HoxN cluster is homologous to the human HoxD cluster.

Sonja J Prohaska, Claudia Fried, Chris T Amemiya, Frank H Ruddle, Günter P Wagner, Peter F Stadler

Bioinformatik, Institut für Informatik, Universität Leipzig, Kreuzstrassse 7b, D-04103 Leipzig, Germany.

Journal of molecular evolution 2004 Feb


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    The statistical analysis of phylogenetic footprints in the two known horn shark Hox clusters and the four mammalian clusters shows that the shark HoxN cluster is HoxD-like. This finding implies that the most recent common ancestor of jawed vertebrates had at least four Hox clusters, including those which are orthologous to the four mammalian Hox clusters.

    Citation

    Sonja J Prohaska, Claudia Fried, Chris T Amemiya, Frank H Ruddle, Günter P Wagner, Peter F Stadler. The shark HoxN cluster is homologous to the human HoxD cluster. Journal of molecular evolution. 2004 Feb;58(2):212-7

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    PMID: 15042342

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