Structure-activity relationships of untenone A and its derivatives for inhibition of DNA polymerases.

Fumiyo Saito, Ryo Takeuchi, Tomoyuki Kamino, Kouji Kuramochi, Fumio Sugawara, Kengo Sakaguchi, Susumu Kobayashi

Frontier Research Center for Genome and Drug Discovery, Tokyo University of Science, 2641 Yamazaki, Noda, Chiba 278-8510, Japan.

Bioorganic & medicinal chemistry letters 2004 Apr 19

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We found that untenone A and mannzamenone A inhibit mammalian DNA polymerases alpha and beta, and human terminal deoxynucleotidyl transferase (TdT). The syntheses of both compounds and the structure-activity relationships of untenone A derivatives are described.

Citation

Fumiyo Saito, Ryo Takeuchi, Tomoyuki Kamino, Kouji Kuramochi, Fumio Sugawara, Kengo Sakaguchi, Susumu Kobayashi. Structure-activity relationships of untenone A and its derivatives for inhibition of DNA polymerases. Bioorganic & medicinal chemistry letters. 2004 Apr 19;14(8):1975-7