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Directionality in intracellular trafficking is essential to ensure the correct localization of proteins along the secretory pathway. Here, we found evidence for an active mechanism that prohibited back-fusion of de novo-generated vesicles with their donor compartment. Tip20p is a peripheral membrane protein implicated in consumption of COPI vesicles at the endoplasmic reticulum. However, a specific mutant of TIP20 did not interfere with COPII vesicle generation but allowed these vesicles to fuse back to the endoplasmic reticulum, a process that does not occur normally in the cell.


Faustin Kamena, Anne Spang. Tip20p prohibits back-fusion of COPII vesicles with the endoplasmic reticulum. Science (New York, N.Y.). 2004 Apr 9;304(5668):286-9

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PMID: 15073376

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