Pseudodeflectusin, a novel isochroman derivative from Aspergillus pseudodeflectus a parasite of the sea weed, Sargassum fusiform, as a selective human cancer cytotoxin.

Akitsu Ogawa, Chikako Murakami, Shinji Kamisuki, Isoko Kuriyama, Hiromi Yoshida, Fumio Sugawara, Yoshiyuki Mizushina

Department of Applied Biological Science, Tokyo University of Science, Noda, Chiba 278-8510, Japan.

Bioorganic & medicinal chemistry letters 2004 Jul 5

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A new isochroman derivative named pseudodeflectusin was isolated from a culture broth of Aspergillus pseudodeflectus. The structure was determined by spectroscopic means as 9-hydroxy-7-methyl-2-(methylethylidine)-furano[3,2-H]isochroman-3-one. This compound exhibited cytotoxicity for several human cancer cell lines from the stomach (NUGC-3), cervix (HeLa-S3), and peripheral blood (HL-60), but did not affect those from the lung (A549) or colon (DLD-1). The LD50 value of this compound for HL-60 cells was 39 microM.

Citation

Akitsu Ogawa, Chikako Murakami, Shinji Kamisuki, Isoko Kuriyama, Hiromi Yoshida, Fumio Sugawara, Yoshiyuki Mizushina. Pseudodeflectusin, a novel isochroman derivative from Aspergillus pseudodeflectus a parasite of the sea weed, Sargassum fusiform, as a selective human cancer cytotoxin. Bioorganic & medicinal chemistry letters. 2004 Jul 5;14(13):3539-43