Drosophila gustatory receptors: from gene identification to functional expression.

Sylwester Chyb

Laboratory of Molecular Physiology, Imperial College London, Wye Campus, Kent TN25 5AH, UK. s.chyb@imperial.ac.uk

Journal of insect physiology 2004 Jun

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Recent years have seen long-awaited progress in understanding of the molecular mechanisms of taste perception in insects. The breakthrough came in the early 2000 with the identification of a novel family of candidate gustatory receptor (Gr) genes in the first release of the Drosophila melanogaster genome sequence. The 60 Gr genes are expressed in the subsets of gustatory neurons in the fly's taste organs and, without exception, encode heptahelical G protein-coupled receptors (GPCRs). Here I review our current knowledge about Gr genes and their products focusing on the newly emerging information regarding the function of the Gr-encoded proteins.

Citation

Sylwester Chyb. Drosophila gustatory receptors: from gene identification to functional expression. Journal of insect physiology. 2004 Jun;50(6):469-77