Novel fluoro- and hydroxyl-containing jasmonate derivatives as highly efficient elicitors in suspension cultures of Taxus chinensis.

Zhenjiang Zhao, Yufang Xu, Zhigang Qian, Wenhong Tian, Xuhong Qian, Jian-Jiang Zhong

Shanghai Key Lab. of Chemical Biology, Institute of Pesticides and Pharmaceuticals, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, China.

Bioorganic & medicinal chemistry letters 2004 Sep 20

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To develop more effective abiotic elicitors for cell suspension cultures of T. chinensis to meet the needs for paclitaxel as anti-tumor drug, some fluoro- or hydroxyl-containing groups are introduced to the ester moiety of jasmonic acid by the esterification or acylation with bis(trichloromethyl) carbonate and corresponding alcohol. Some of them are found to be novel and effective elicitors, which can enhance the production of taxuyunnanine C (Tc) up to 60% more than that by methyl jasmonate (MJA) in T. chinensis cell cultures.

Citation

Zhenjiang Zhao, Yufang Xu, Zhigang Qian, Wenhong Tian, Xuhong Qian, Jian-Jiang Zhong. Novel fluoro- and hydroxyl-containing jasmonate derivatives as highly efficient elicitors in suspension cultures of Taxus chinensis. Bioorganic & medicinal chemistry letters. 2004 Sep 20;14(18):4755-8