Distribution of amphotericin B-arabinogalactan conjugate in mouse tissue and its therapeutic efficacy against murine aspergillosis.

Rama Falk, Jacob Grunwald, Amnon Hoffman, Abraham J Domb, Itzhack Polacheck

Department of Clinical Microbiology and Infectious Diseases, The Hebrew University-Hadassah Medical Center, P.O. Box 12000, Jerusalem 91120, Israel.

Antimicrobial agents and chemotherapy 2004 Sep

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The pharmacokinetic characteristics and tissue distribution of a novel water-soluble, nontoxic amphotericin B-arabinogalactan (AMB-AG) conjugate exhibited distinct differences from those of micellar and liposomal amphotericin B formulations. These differences included extended persistence of drug in the body and its accumulation in the lungs; thus, the AMB-AG conjugate was highly effective in treating systemic murine aspergillosis.

Citation

Rama Falk, Jacob Grunwald, Amnon Hoffman, Abraham J Domb, Itzhack Polacheck. Distribution of amphotericin B-arabinogalactan conjugate in mouse tissue and its therapeutic efficacy against murine aspergillosis. Antimicrobial agents and chemotherapy. 2004 Sep;48(9):3606-9