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Regulation of bone mineralization by enzymes].
Takuo Kubota, Keiichi Ozono
Department of Developmental Medicine, Osaka University Graduate School of Medicine.
Clinical calcium 2004 Jun
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The enzymes, such as TNSALP regulate bone mineralization, and the mineralization inhibitor inorganic pyrophosphate (PPi) plays a central role in the process. NPP1 and ANK increase PPi concentration in the extracellular matrix, while TNSALP hydrolyzes PPi. The analyses using knock-out mice demonstrated that NPP1 and ANK, and TNSALP are antagonistic regulators for PPi. Concerted regulation of PPi by TNSALP, NPP1, and ANK, leads bone mineralization to be regulated strictly.
Citation
Takuo Kubota, Keiichi Ozono.
Regulation of bone mineralization by enzymes].
Clinical calcium.
2004 Jun;14(6):23-7
Mesh Tags
Alkaline Phosphatase
Animals
Calcification, Physiologic
Cystathionine beta-Synthase
Diphosphates
Extracellular Matrix
Humans
Membrane Proteins
Methylenetetrahydrofolate Reductase (NADPH2)
Mice
PHEX Phosphate Regulating Neutral Endopeptidase
Phosphate Transport Proteins
Phosphoric Diester Hydrolases
Proteins
Pyrophosphatases
Substances
ANKH protein, human
Diphosphates
Membrane Proteins
Phosphate Transport Proteins
Proteins
ank protein, mouse
Methylenetetrahydrofolate Reductase (NADPH2)
Alkaline Phosphatase
Phosphoric Diester Hydrolases
PHEX Phosphate Regulating Neutral Endopeptidase
PHEX protein, human
Phex protein, mouse
Pyrophosphatases
nucleotide pyrophosphatase - phosphodiesterase I
Cystathionine beta-Synthase
PMID: 15577050
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