Molecular aspects of the transport and toxicity of ochratoxin a.

Jian Dai, Gyungse Park, Jennifer L Perry, Yuri V Il'ichev, Daniel A J Bow, John B Pritchard, Virginie Faucet, Annie Pfohl-Leszkowicz, Richard A Manderville, John D Simon

Department of Chemistry, Wake Forest University, Winston-Salem, North Carolina 27106, USA.

Accounts of chemical research 2004 Nov

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Ochratoxins are a class of naturally occurring compounds produced by several fungi. The most toxic is ochratoxin A (OTA), and occurrence of some human nephropathies and tumors correlate with enhanced OTA exposure. In this Account, the following areas are examined: molecular details of the binding of OTA to human serum albumin (HSA), the influences of binding to HSA on the trans-port of OTA across epithelial cell membranes by organic anion transport proteins, the oxidative activation of OTA, and the formation of OTA adducts with biological molecules. These studies are beginning to provide a detailed chemical model for the trans-port, accumulation, and genotoxic and carcinogenic effects of OTA.

Citation

Jian Dai, Gyungse Park, Jennifer L Perry, Yuri V Il'ichev, Daniel A J Bow, John B Pritchard, Virginie Faucet, Annie Pfohl-Leszkowicz, Richard A Manderville, John D Simon. Molecular aspects of the transport and toxicity of ochratoxin a. Accounts of chemical research. 2004 Nov;37(11):874-81