Signaling mechanisms for regulation of chemotaxis.

Department of Genetics and Developmental Biology, University of Connecticut Health Center, Farmington, CT 06030, USA. dwu@neuron.uchc.edu

Cell research 2005 Jan

Chemotaxis is a fascinating biological process, through which a cell migrates along a shallow chemoattractant gradient that is less than 5% difference between the anterior and posterior of the cell. Chemotaxis is composed of two independent, but interrelated processes-motility and directionality, both of which are regulated by extracellular stimuli, chemoattractants. In this mini-review, recent progresses in the understanding of the regulation of leukocyte chemotaxis by chemoattractant signaling are reviewed.