Identification and characterization of human ZNF18 gene in silico.

Kenichi Yoshida

Department of Life Sciences, Meiji University, Tama-ku, Kawasaki, Kanagawa 214-8571, Japan. yoshida@isc.meiji.ac.jp

International journal of molecular medicine 2005 Mar

filter terms:

Zinc finger protein genes are regulatory transcription factors that interact directly with DNA and/or RNA. Here, we identified the ZNF18 gene by using bioinformatics. Human ZNF18 gene, consisting of 9 exons, was located within human genome sequences RP11-1096G20 (AC005410.3). Complete coding sequence of human ZNF18 cDNA was determined by FLJ35337 cDNA (AK092656), which was identified by using partial coding sequence of human ZNF18 cDNA (X52342) as a query. Human, mouse, and rat ZNF18 showed 77-92% total-amino acid identity. N-terminal leucine rich region, krueppel-associated box, and C-terminal three C2H2 type zinc finger motifs were identified within ZNF18 protein. This is the first report on identification and characterization of the ZNF18 gene.

Citation

Kenichi Yoshida. Identification and characterization of human ZNF18 gene in silico. International journal of molecular medicine. 2005 Mar;15(3):545-8