Silica coatings on clarithromycin.

Marjan Bele, Dorde Dmitrasinovic, Odon Planinsek, Mateja Salobir, Stane Srcic, Miran Gaberscek, Janko Jamnik

National Institute of Chemistry Slovenia, Hajdrihova 19, 1000 Ljubljana, Slovenia. marjan.bele@ki.si

International journal of pharmaceutics 2005 Mar 3

filter terms:

Pre-crystallized clarithromycin (6-O-methylerythromycin A) particles were coated with silica from the tetraethyl orthosilicate (TEOS)-ethanol-aqueous ammonia system. The coatings had a typical thickness of 100-150 nm and presented about 15 wt.% of the silica-drug composite material. The properties of the coatings depended on reactant concentration, temperature and mixing rate and, in particular, on the presence of a cationic surfactant (cetylpyridinium chloride). In the presence of cetylpyridinium chloride the silica coatings slightly decreased the rate of pure clarithromycin dissolution.

Citation

Marjan Bele, Dorde Dmitrasinovic, Odon Planinsek, Mateja Salobir, Stane Srcic, Miran Gaberscek, Janko Jamnik. Silica coatings on clarithromycin. International journal of pharmaceutics. 2005 Mar 3;291(1-2):149-53