In vitro and in vivo activities of newly synthesized fluoroquinolones WQ-3345 and WQ-3402 against Mycobacterium leprae].

Leprosy Research Center, National institute of Infectious Diseases 4-2-1, Aoba-cho, Higashimurayama-shi, Tokyo 189-0002, Japan. m-gidoh@nih.go.jp

Nihon Hansenbyō Gakkai zasshi = Japanese journal of leprosy : official organ of the Japanese Leprosy Association 2005 Feb

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Activities of newly synthesized fluoroquinolnes WQ-3345 and WQ-3402 against M. leprae were measured by using the Buddemeyer method. The % inhibition of the examined drugs for M. leprae was in the order of RFP > WQ-3402 > SPFX > GFLX > WQ-3345 > LVFX. The anti-M. leprae activity of WQ-3402 was found to be strongest in these five fluoroquinolones when examined by this method, and the activity of WQ-3345 was weaker than that of GFLX. The anti-M. leprae activities of WQ-3345 and WQ-3402 were measured by a mouse footpad method using nude mice. The inhibitory effects on the growth of M. leprae inoculated into the footpads were found to be incomplete after orally administered with WQ-3345 or WQ-3402 respectively at dosages of 10 and 20 mg/kg, and the incomplete inhibition was again was again found even at a dosage of 30, 40, or 50 mg/kg im the latter.

Citation

Masaichi Gidoh. In vitro and in vivo activities of newly synthesized fluoroquinolones WQ-3345 and WQ-3402 against Mycobacterium leprae]. Nihon Hansenbyō Gakkai zasshi = Japanese journal of leprosy : official organ of the Japanese Leprosy Association. 2005 Feb;74(1):43-8