Cytotoxic flavonoids from Platymiscium floribundum.

Curso de Pós-Graduação em Química Orgânica, Departamento de Química Orgânica e Inorgânica, Centro de Ciências, Universidade Federal do Ceará, CP 12200, Fortaleza-Ce, 60021-940, Brazil.

Journal of natural products 2005 Mar

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Two new isoflavonoids, 7-hydroxy-6,4'-dimethoxy-isoflavonequinone (1) and 2'-hydroxy-6,4',6' ',4' ''-tetramethoxy-[7-O-7' ']-bisisoflavone (2), and seven other known flavonoids, 3-hydroxy-9-methoxypterocarpan (medicarpin), 3,10-dihydroxy-9-methoxypterocarpan, 3,9-dimethoxypterocarpan (homopterocarpin) (3), 2,3,9-trimethoxypterocarpan (4), 3,4-dihydroxy-9-methoxypterocarpan (vesticarpan) (5), 2',4,4'-trihydroxychalcone (isoliquiritigenin), and 7,4'-dihydroxyflavanone (liquiritigenin) (6), were isolated from the heartwood of Platymiscium floribundum. The structures of compounds 1 and 2 were established by spectroscopic methods. Compounds 3-6 showed cytotoxic activity when evaluated against five human cancer cell lines in vitro.

Citation

Maria José C Falcão, Yvone Brígido M Pouliquem, Mary Anne S Lima, Nilce Viana Gramosa, Letícia V Costa-Lotufo, Gardênia Carmen G Militão, Cláudia Pessoa, Manoel Odorico de Moraes, Edilberto R Silveira. Cytotoxic flavonoids from Platymiscium floribundum. Journal of natural products. 2005 Mar;68(3):423-6