Experimental demonstration that mammalian oocytes are not selective towards X- or Y-bearing sperm.

Mammalian oocytes are thought to be neutral as for X- or Y-bearing sperm selection is concerned, and penetration of an oocyte by an X- or a Y-bearing sperm is considered a random event. This assumption is mainly based on a posteriori evidences of a nearly equal sex ratio at birth, but it has never been experimentally demonstrated. We have designed a simple experiment, which allowed the penetration of an oocyte by more than one sperm and the further sexing by PCR of each single pronucleus present within the ooplasm. For the first time, we provide experimental evidence that mammalian oocytes do not play a selecting role since a single oocyte may be simultaneously fertilised by both X- and Y-bearing sperm. Copyright 2005 Wiley-Liss, Inc

Citation

Maurizio Zuccotti, Vittorio Sebastiano, Silvia Garagna, Carlo Alberto Redi. Experimental demonstration that mammalian oocytes are not selective towards X- or Y-bearing sperm. Molecular reproduction and development. 2005 Jun;71(2):245-6

Mesh Tags

PMID: 15791593

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