Levofloxacin and ciprofloxacin decrease procainamide and N-acetylprocainamide renal clearances.

Larry A Bauer, Douglas J Black, Jennifer S Lill, Julie Garrison, Vidmantas A Raisys, Thomas M Hooton

Department of Pharmacy, Box 357630, University of Washington, Seattle, WA 98195. labauer@u.washington.edu.

Antimicrobial agents and chemotherapy 2005 Apr

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Ten healthy adults participated in a randomized, crossover drug interaction study testing procainamide only, procainamide plus levofloxacin, and procainamide plus ciprofloxacin. During levofloxacin therapy, most procainamide and N-acetylprocainamide (NAPA) pharmacokinetic parameters, including decreased renal clearances and renal clearance/creatinine clearance ratios, changed (P < 0.05). During ciprofloxacin treatment, only procainamide and NAPA renal clearances decreased significantly.

Citation

Larry A Bauer, Douglas J Black, Jennifer S Lill, Julie Garrison, Vidmantas A Raisys, Thomas M Hooton. Levofloxacin and ciprofloxacin decrease procainamide and N-acetylprocainamide renal clearances. Antimicrobial agents and chemotherapy. 2005 Apr;49(4):1649-51