Leptolide, a new furanocembranolide diterpene from Leptogorgia alba.

Marcelino Gutiérrez, Todd L Capson, Héctor M Guzmán, José González, Eduardo Ortega-Barría, Emilio Quiñoá, Ricardo Riguera

Departamento de Química Orgánica, Instituto de Acuicultura y Unidad de RMN de Biomoléculas Asociada al CSIC, Universidad de Santiago de Compostela, E-15782 Santiago de Compostela, Spain.

Journal of natural products 2005 Apr

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Six furanocembranolides (1-6) and one pseudopterolide (7) have been isolated from the octocorals Leptogorgia alba and Leptogorgia rigida, collected on the Pacific coast of Panama. Compound 1, named leptolide, has a new structure closely related to the neurotoxin lophotoxin (3). The X-ray structures of 1-3 were determined, and the absolute configurations of 2-7 are discussed. Compounds 1-7 were evaluated in vitro against drug-resistant Plasmodium falciparum.

Citation

Marcelino Gutiérrez, Todd L Capson, Héctor M Guzmán, José González, Eduardo Ortega-Barría, Emilio Quiñoá, Ricardo Riguera. Leptolide, a new furanocembranolide diterpene from Leptogorgia alba. Journal of natural products. 2005 Apr;68(4):614-6