Pre-pro-somatostatin-III may have cortistatin-like functions in fish.

Luis Fabián Canosa, Richard Ector Peter

Department of Biological Sciences, University of Alberta, Edmonton, Canada.

Annals of the New York Academy of Sciences 2005 Apr

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This study analyzes daily changes in the expression of somatostatin precursors PSS-I and PSS-III (structurally related to cortistatin) in the goldfish brain. The results indicate that PSS-I expression correlates with the light cycle only in optic tectum-thalamus (OT-Tha). PSS-III expression correlates with the light cycle in telencephalon-preoptic area (Tel-POA) and OT-Tha. In Tel-POA, PSS-III reaches a minimum level at the beginning of the active phase and a maximum level late in this phase. These results suggest that PSS-I in OT-Tha and PSS-III in Tel-POA and OT-Tha could be involved in the control of the activity cycles in goldfish.

Citation

Luis Fabián Canosa, Richard Ector Peter. Pre-pro-somatostatin-III may have cortistatin-like functions in fish. Annals of the New York Academy of Sciences. 2005 Apr;1040:253-6