Phytotoxins from the fungus Malbranchea aurantiaca.

Sergio Martínez-Luis, María C González, Miguel Ulloa, Rachel Mata

Departamento de Farmacia, Facultad de Química, Universidad Nacional Autónoma de México, D.F. 04510, México.

Phytochemistry 2005 May

filter terms:

Bioassay-directed fractionation of an ethyl acetate extract from cultures of the fungus Malbranchea aurantiaca led to the isolation of two phytotoxic compounds, namely, 1-hydroxy-2-oxoeremophil-1(10),7(11),8(9)-trien-12(8)-olide (1) and penicillic acid (2). The structure of 1 was established by spectroscopic and X-ray crystallographic analyses. Metabolites 1 and 2 caused significant inhibition of radicle growth of Amaranthus hypochondriacus with IC(50) values 6.57 and 3.86 microM, respectively. In addition, 1 inhibited activation of the calmodulin-dependent enzyme cAMP phosphodiesterase (IC(50)=10.2 microM).

Citation

Sergio Martínez-Luis, María C González, Miguel Ulloa, Rachel Mata. Phytotoxins from the fungus Malbranchea aurantiaca. Phytochemistry. 2005 May;66(9):1012-6