Glaciapyrroles A, B, and C, pyrrolosesquiterpenes from a Streptomyces sp. isolated from an Alaskan marine sediment.

Venkat R Macherla, Jehnan Liu, Christopher Bellows, Sy Teisan, Benjamin Nicholson, Kin S Lam, Barbara C M Potts

Nereus Pharmaceuticals, Inc., 10480 Wateridge Circle, San Diego, California 92121, USA.

Journal of natural products 2005 May

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A Streptomyces sp. (NPS008187) isolated from a marine sediment collected in Alaska was found to produce three new pyrrolosesquiterpenes, glyciapyrroles A (1), B (2), and C (3), along with the known diketopiperazines cyclo(leucyl-prolyl) (4), cyclo(isoleucyl-prolyl) (5), and cyclo(phenylalanyl-prolyl) (6). The structures of 1, 2, and 3 were established using spectroscopic methods.

Citation

Venkat R Macherla, Jehnan Liu, Christopher Bellows, Sy Teisan, Benjamin Nicholson, Kin S Lam, Barbara C M Potts. Glaciapyrroles A, B, and C, pyrrolosesquiterpenes from a Streptomyces sp. isolated from an Alaskan marine sediment. Journal of natural products. 2005 May;68(5):780-3