Lipoxygenase inhibiting ethyl substituted glycoside from Symplocos racemosa.

Muhammad Athar Abbasi, Viqar Uddin Ahmad, Muhammad Zubair, Sarfraz A Nawaz, Muhammad Arif Lodhi, Umar Farooq, M Iqbal Choudhary

HEJ Research Institute of Chemistry, International Center for Chemical Sciences University of Karachi, Karachi 75270, Pakistan. atrabbasi@yahoo.com

Natural product research 2005 Jul

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Phytochemical investigation of Symplocos racemosa resulted in the isolation of a new ethyl substituted glycoside, 1-ethyl brachiose-3'-acetate (1) along with four known compounds ketochaulmoogric acid (2), nonaeicosanol (3), triacontyl palmitate (4) and methyl triacontanoate (5). The substitution of ethyl group on 1 was natural because during the course of extraction and purification ethanol was not used. The structural elucidation of the isolated compounds was based primarily on 1D- and 2D-NMR analysis, including COSY, HMQC, and HMBC correlations. The glycoside 1 and triacontyl palmitate (4) displayed the inhibitory potential against lipoxygenase and urease enzyme, respectively.

Citation

Muhammad Athar Abbasi, Viqar Uddin Ahmad, Muhammad Zubair, Sarfraz A Nawaz, Muhammad Arif Lodhi, Umar Farooq, M Iqbal Choudhary. Lipoxygenase inhibiting ethyl substituted glycoside from Symplocos racemosa. Natural product research. 2005 Jul;19(5):509-15