Pseudopyronines A and B, alpha-pyrones produced by a marine Pseudomonas sp. F92S91, and evidence for the conversion of 4-hydroxy-alpha-pyrone to 3-furanone.

Fangming Kong, Maya P Singh, Guy T Carter

Chemical and Screening Sciences, Wyeth Research, Pearl River, New York 10965, USA. kongf@wyeth.com

Journal of natural products 2005 Jun

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In our search for inhibitors of bacterial fatty acid biosynthesis, two new alpha-pyrones, pseudopyronines A (1) and B (2), were isolated from a marine Pseudomonas sp. F92S91. The naturally occurring alpha-pyrones appeared to be unstable, evidenced by the conversion of pseudopyronine B into an oxidation product, 3-furanone (3). Structural elucidations were made by spectroscopic analyses including 2D-NMR data.

Citation

Fangming Kong, Maya P Singh, Guy T Carter. Pseudopyronines A and B, alpha-pyrones produced by a marine Pseudomonas sp. F92S91, and evidence for the conversion of 4-hydroxy-alpha-pyrone to 3-furanone. Journal of natural products. 2005 Jun;68(6):920-3